Cis-acting variation is common across regulatory layers but is often buffered during embryonic development
نویسندگان
چکیده
منابع مشابه
HSP90-buffered genetic variation is common in Arabidopsis thaliana.
HSP90 is a protein chaperone particularly important in the maturation of a diverse set of proteins that regulate key steps in a multitude of biological processes. Alterations in HSP90 function produce altered phenotypes at low penetrance in natural populations. Previous work has shown that at least some of these phenotypes are due to genetic variation that remains phenotypically cryptic until i...
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The interaction between transcription factors and their DNA binding sites plays a key role for understanding gene regulation mechanisms. Recent studies revealed the presence of “functional polymorphism” in genes that is defined as regulatory variation measured in transcription levels due to the cis-acting sequence differences. These regulatory variants are assumed to contribute to modulating ge...
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Gene expression levels vary heritably, with approximately 25-35% of the loci affecting expression acting in cis. We characterized standing cis-regulatory variation among 16 wild-derived strains of Drosophila melanogaster. Our experiment's robust biological and technical replication enabled precise estimates of variation in allelic expression on a high-throughput SNP genotyping platform. We obse...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2020
ISSN: 1088-9051,1549-5469
DOI: 10.1101/gr.266338.120